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KMID : 0616120220530030153
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 3 p.153 ~ p.161
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Protective Effect of Cotoneaster mongolicus Pojark. Extract in HCl/ethanol-induced Gastritis Mice
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Choi Jeong-Won
Lee Jin-A.
Shin Mi-Rae
Park Hae-Jin
Roh Seong-Soo
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Abstract
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Cotoneaster mongolicus Pojark. (CM), in the family Rosaceae is an endemic plant to the Mongolian region (its name: Монгол чаргай). In Mongolia, Cotoneaster species as a crude drug is mainly used for inflammatory diseases, diarrhea, and stomach indigestion. In this study, we evaluated the gastro-protective activity underlying mechanism of CM. For in vivo experiments, mice were divided into 5 groups; normal mice (Normal), gastritis mice (Control), gastritis mice treated with sucralfate 10 mg/kg (SC), gastritis mice treated with CM 100 mg/kg (CML), gastritis mice treated with CM 200 mg/kg (CMH). Gastritis was provoked by HCl/ethanol (60% ethanol in 150 mM HCl). After oral administration of each drug, HCl/ethanol was orally administered 90 mins later to induce gastritis. CM alleviated the damage to the gastric mucosa caused. As a result of confirming the expression of protein in gastric tissue through western blot, CM significantly reduced the expression of NF-κB activated due to gastritis. Also, it significantly modulated the Nrf2-Keap1 pathway. These results indicate that CM not only inhibits the nuclear metastasis of NF-κB but also modulates the Nrf2-Keap1 pathway to relieve inflammation of the gastric mucosa.
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KEYWORD
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Cotoneaster mongolicus, Acute gastritis, Gastric mucosal lesions, Anti-inflammatory, Antioxidant
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